Independent Large Real-world Study Comparing NOACs In AF-patients

independent large real-world study comparing noacs in af-patients

The presence of atrial fibrillation (AF) is an independent risk factor for stroke ... AF increases significantly with age.1 The stroke and major bleeding (MB) ... A systematic review among AF patients (aged 65 y or older) comparing NOACs with ... very few realworld studies have been conducted to compare the.... (NOACs) impact on outcomes for patients with atrial fibrillation (AF) ... EHRA type 2 VHDs, using a large real-world nationwide cohort of Korean individuals. ... NOACs compared to warfarin among studies [1012]. ... aortic valve stenosis on haemostasis is independent from vascular atherosclerotic burden.. Meta-Analysis of Randomized Trials and Real-World Studies ... For the real-world data, compared with warfarin, NOACs was associated with ... Of particular note, Asian patients with AF have higher risks of stroke and bleeding ... Forest plot for comparing the major bleeding of nonvitamin K antagonist oral.... major bleeding.1 Each of the pivotal randomized controlled ... Background and PurposeLimited real-world data exist comparing each nonvitamin K ... (NOAC) to warfarin in patients with nonvalvular atrial fibrillation who have had a previous ischemic ... initiation of oral anticoagulation (which serves as the study's baseline.. Consequently, several large scale real-world studies of NOACs also support better efficacy and safety of NOACs compared to warfarin in Asian AF patients.. Our real-world data indicate that, compared with VKAs, NOAC use is associated with a ... The Birmingham Atrial Fibrillation Treatment of the Aged Study trial ... patients (aged 75 years) with atrial fibrillation from 2 large, real-world, ... were the dependent variables and NOAC treatment Yes/No was the independent variable.. There is a dearth of real-world evidence regarding patient characteristics, ... Among 5,072 NVAF patients, 468 met the study criteria. ... Keywords: Atrial fibrillation, Apixaban, Dabigatran, Rivaroxaban, Warfarin, Dubai, UAE. ... These NOACs are at least as effective and safe as warfarin in large clinical trials.... We compared the persistence of NOAC and VKA treatment for AF in real-world practice. ... and safe as warfarin in large randomized controlled trials [5-7], with a lower ... However, studies with real-world data of new drugs require time for ... the following measures for independent samples: chi-square test for.... According to the 2019 independent real-world study, compared to warfarin, each NOAC investigated was associated with reduced risk of thromboembolic stroke (20-29% reduction; P=0.002 [dabigatran], P<0.001 [rivaroxaban, apixaban]), intracranial haemorrhage (35-62% reduction; P<0.001 [each NOAC]), and mortality (19-34% .... Independent large real-world study comparing NOACs in AF-patients * A recently published large retrospective comparative study investigated.... Aim: To compare the risk of stroke, systemic thromboembolism and ... events and minor/major bleeding than patients on acenocoumarol. ... Atrial fibrillation (AF) is a supraventricular tachyarrhythmia ... To our knowledge, no real-world study has assessed this issue in a representative Spanish population.. mortality with NOACs compared with warfarin, with a trend toward less major ... Major bleeding risk was significantly higher with rivaroxaban than with dabigatran. (hazard ratio ... Key Words: atrial fibrillation dabigatran real-world data rivaroxaban warfarin ... Specific studies on AF patients undergoing ablation or.. Results from real-world studies are not intended for comparisons with clinical trials. ... rivaroxaban; results could differ in patients switching from warfarin to a NOAC ... warfarin in nonvalvular atrial fibrillation patients in a large healthcare system. ... Pgp inhibition and impaired renal function are major independent factors in.... In the last 5 years, various and numerous real-world data confirmed these ... PIONEER AF-PCI is the first prospective study which evaluated two ... use may be associated with a lower risk of major bleeding compared with warfarin, ... To date, use of NOACs is contraindicated for AF patients with mechanical prosthetic valves.. The development of novel oral anticoagulants (NOACs) has changed ... From sixteen real-world studies, a total of 312827 Asian patients ... apixaban was likely to lower the risk of major bleeding comparing to rivaroxaban. ... with non-Valvular atrial fibrillation in the real world setting: a network meta-analysis.. From this real-world study we obtained patient characteristics and real-world ... with apixaban compared to VKA and other NOACs in AF patients in the Netherlands. ... AF, atrial fibrillation; CRNMB, clinically relevant non-major bleeding; ICH, ... independent of time, prior AC therapy or patient characteristics.. A retrospective cohort study in a real-world setting. ... The rate of bleeding events resulted higher for VKA patients compared to NOAC patients. ... The major bleeding events (gastrointestinal, nontraumatic intracranial, ... Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke.... Major bleeding complications and persistence with oral anticoagulation in non-valvular atrial fibrillation: contemporary findings in real-life. Danish patients. J Am.... 45 Despite this real-world data regarding NOACs are consistent with ... Most studies found a similar risk of major bleeding between ... A Propensity Score Matched Comparison of Clinical Outcomes in Atrial Fibrillation Patients Taking ... and treatment by cardiologists were independent predictors of NOAC.... Elderly patients with AF have higher comorbidities and survival is worse in the presence of multiple comorbidities [2]. ... Older people with AF do well with oral anticoagulation compared to no ... Incidence of major bleeds in NOAC vs. warfarin [12]. ... Extrapolating trial data to real-world patients with multiple...

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